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KMID : 0624620190520050312
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BMB Reports
2019 Volume.52 No. 5 p.312 ~ p.317
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MiR-371 promotes proliferation and metastasis in hepatocellular carcinoma by targeting PTEN
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Wang Hao
Zhao Yi
Chen Tingsong
Liu Guofang
He Nan
Hu Heping
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Abstract
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Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality worldwide. MiR-371 has recently emerged as an important regulator in tumorigenesis, and may serve as a biomarker for malignant tumors. We transfected miR-371 or its inhibitor in two human HCC cell lines, then used 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, soft agar colony formation, and transwell migration assays to evaluate the effects on cell proliferation, migration, and invasion. We found that miR-371 was positively correlated with HCC metastasis and poor prognosis in the inflicted patients, and the high expression of miR-371 was promoted, whereas a low level of miR-371 depressed cell proliferation and invasion. We found PTEN to be a direct target of miR-371. The overexpression or knockdown of PTEN exhibited the opposite effects from those of miR-371 on cell proliferation and migration. Our study demonstrates that miR-371 promotes proliferation and metastasis in HCC by targeting PTEN.
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KEYWORD
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Cancer, Hepatocellular carcinoma, Metastasis, miR-371, PTEN
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